Based on what happened next, I ASSUME
it means, "Would you like an enema?"
The Big Bang Theory Season 1, Episode 11
I ASSUME we're talking
about you now?
The Big Bang Theory Season 5, Episode 23
Clearly it would not be appropriate
for a woman to ASSUME that role.
Game of Thrones Season 5, Episode 2
No, let's ASSUME that they can.
The Big Bang Theory Season 1, Episode 2
All right, let's ASSUME
your dreams come true.
Game of Thrones Season 5, Episode 6